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30 years of cell culture excellence

Author: Maya Rotman

The future of T-cell manufacturing for immunotherapy – an interview with Dr. Ohad Karnieli

Cancer treatment has evolved in recent years from unspecific aggressive treatments, such as radiotherapy and chemotherapy, to new and more specific immune therapies.  In recent years, new therapies called immune cell therapy or Adoptive Cell Transfer (ACT) have evolved. These therapies aim to activate and “educate” the immune system to attack the tumor. CAR-T (Chimeric Antigen Receptor) is one such therapy in which T cells from the patient are “engineered” outside the body, activated, expanded, and reinfused to the patient.  Such therapies have shown unprecedented clinical efficacy in Leukemia where above 80% of end-stage patients showed remission. The problem is, these treatments...

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How a 300µm gastruloid can shed light on human development

Gastrulation is an early stage in fetal development, occurring two weeks after conception. During gastrulation, the fetus (or blastula, to be exact), which until then had been a hollow single-layered sphere of cells, develops into a three-layered cell structure known as a gastrula. (Figure 1) Figure 1: Gastrulation. A diagram of the transformation from a fertilized egg (a zygote) to a gastrula. These three germ layers are the endoderm, mesoderm and ectoderm, from which all body systems, tissues and organs will later develop. (Figure 2) Since the law prohibits growing embryonic cell cultures ex-vivo, beyond two weeks from the...

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The story of Organoids

Over the past few decades, scientists put great efforts into trying to ‘crack’ the great mystery of cell communication and tissue assembly. Although in vitro 2D cell cultures have been widely used and serve as an important research tool, the lack of tissue architecture and the complexity of such models do not fully reflect the true biological processes in vivo. The way to tackle these obstacles took shape in three-dimensional (3D) models referred to as ‘Organoids’. These 3D models aim to recapitulate the cellular heterogeneity, structure and functions of the primary tissues. What is an Organoid? The term Organoid...

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